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Evidence caveat: The combination approach is based on clinical observation and mechanistic reasoning, not controlled trials

Although our data align with the notion that inhibiting NMDA receptor signalling in the hypothalamus decreases food intake and body weight 8,40 , earlier studies have demonstrated that NMDA receptor antagonism in the brainstem attenuates vagus-mediated meal-related satiety 6,7,42

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Glutathione is the primary carrier in Phase II